¿Tiene la jalea real un efecto reproductivo en cabras tratadas con progesterona?
Investigación
Lorenzo Alvarez Ramírez 
Universidad Nacional Autónoma de México
email: alorenzo@unam.mx
Alejandra Sánchez Cervantes
Universidad Nacional Autónoma de México
email: alorenzo@unam.mx
Introducción: Algunos métodos para la inducción/sincronización del estro/ovulación en cabras requieren de gonadotropina coriónica equina (eCG). El objetivo del estudio fue determinar si la jalea real (JR) puede ser un sustituto para la eCG en cabras lecheras tratadas con el dispositivo CIDR.
Métodos: En el mes de abril, 66 cabras primerizas fueron tratadas con el dispositivo CIDR durante doce días. El grupo eCG (n=22) recibió una inyección de 200 UI de eCG al retiro del dispositivo. El grupo JR (n=22) recibió una inyección intramuscular diaria de 1 g de JR durante el periodo de uso del CIDR. El grupo CIDR (n=22) no recibió tratamiento adicional. Se incluyó un grupo control (Con, n=20) que no recibió tratamiento alguno durante todo el estudio. Se registró la respuesta estral, ovulación y la fertilidad.
Resultados: El porcentaje de animales en estro fue mayor en el grupo eCG (95%, p<0.05) que en los otros (RJ, 41%; CIDR, 36% and Con, 0%) y se presentó en un intervalo menor (eCG, 35±2.3; RJ, 66±4.6; CIDR, 59±2; h±ee; p<0.05). El porcentaje de ovulación fue mayor en el grupo eCG (91%, p<0.05); no se encontraron diferencias entre JR y CIDR (50% vs 41%, p>0.05). No se registró ovulación en el grupo Con. El porcentaje de fertilidad fue mayor en el grupo eCG (91%, p<0.05) comparado con los otros grupos (JR, 36%; CIDR, 36%, Con, 0%), mientras que JR y CIDR no fueron diferentes (p>0.05).
Conclusión: No se encontró evidencia de un efecto reproductivo de la JR en cabras tratadas con progesterona.
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[2] Simões J. Recent Advances on Synchronization of Ovulation in Goats, out of Season, for a More Sustainable Production. Asian Pac J Reprod. 2015; 4(2):157–65. https://doi.org/10.1016/S2305-0500(15)30014-2.
[3] Wheaton JE, Carlson KM, Windels HF, Johnston LJ. CIDR: A new progesterone-releasing intravaginal device for induction of estrus and cycle control in sheep and goats. Anim Reprod Sci. 1993; 33:127-141. doi: https://doi.org/10.1016/0378-4320(93)90111-4.
[4] Freitas VJF, Baril G, Saumande J. Estrus synchronization in dairy goats: use of fluorogestone acetate vaginal sponges or norgestomet ear implants. Anim Reprod Sci. 1997; 46:237-244. doi: https://doi.org/10.1016/S0378-4320(96)01614-4.
[5] Wildeus S. Current concepts in synchronization of estrus: Sheep and goats. J Anim Sci. 2000; 77:1-14. doi: https://doi.org/10.2527/jas2000.00218812007700ES0040x.
[6] Menchaca A, Rubianes E. New treatments associated with timed artificial insemination in small ruminants. Reprod Fertil Devel. 2004; 16:403-413. doi: https://doi.org/10.1071/RD04037.
[7] Whitley NC, Jackson DJ. An update on estrus synchronization in goats: A minor species. J Anim Sci. 2004;82: E270-276. doi: https://doi.org/10.2527/2004.8213_supplE270x.
[8] Hamra AH, McNally JW, Marcek JM, Carlson KM, Wheaton JE. Comparison of progesterone sponges, cronolone sponges and controlled internal drug release dispensers on fertility in anestrous ewes. Anim Reprod Sci. 1989; 18:219-226. doi: https://doi.org/10.1016/0378-4320(89)90023-7.
[9] Umberger SH, Jabbar G, Lewis GS. Seasonally anovulatory ewes fail to respond to progestogen treatment in the absence of gonadotropin stimulation. Theriogenology 1994; 42:1329-1336. doi: https://doi.org/10.1016/0093-691X(94)90253-F.
[10] Zaiem I, Tainturier D, ChemLi J, Soltani M. Vaginal sponges and different PMSG doses to improve breeding performances of Black Thibar ewes. Rev Méd Vét 1996; 147:305-310.
[11] Wheaton JE, Pohl HA, Windels HF. Effects of melatonin and progesterone administered to ewes in spring and summer. J Anim Sci. 1990;68(4):923–30. doi: https://doi.org/10.2527/1990.684923x.
[12] Alifakiotis T, Michailidis I, Gavrilidis G. Induced breeding in anestrous milking ewes of dairy breeds: Comparison of norgestomet, medroxyprogesterone and fluorogestone in two regimes of PMSG. Theriogenology 1982; 17:603-610. doi: https://doi.org/10.1016/0093-691X(82)90058-9.
[13] Ritar AJ, Salamon S, Ball PD, O’May PJ. Ovulation and fertility in goats after intravaginal device-PMSG treatment. Small Rumin Res. 1989;2(4):323–31. doi: https://doi.org/10.1016/0921-4488(89)90027-8.
[14] Langford GA. Influence of PMSG and time of artificial insemination on fertility of progestogen-treated sheep in confinement. J Anim Sci. 1982;54(6):1205–11. doi: https://doi.org/10.2527/jas1982.5461205x.
[15] Quintero-Elisea JA, Macías-Cruz U, Álvarez-Valenzuela FD, Correa-Calderón A, González-Reyna A, Lucero-Magaña FA, Soto-Navarro SA, Avendaño-Reyes L. The effects of time and dose of pregnant mare serum gonadotropin (PMSG) on reproductive efficiency in hair sheep ewes. Trop Anim Heal Prod. 2011;43(8):1567–73. doi: https://doi.org/10.1007/s11250-011-9843-z.
[16] Bodin L, Drion PV, Remy B, Brice G, Cognié Y, Beckers JF. Anti-PMSG antibody levels in sheep subjected annually to oestrus synchronisation. Reprod Nutr Dev. 1997; 37:651-660. doi: https://doi.org/10.1051/rnd:19970604.
[17] Roy F, Combes B, Vaiman D, Cribiu E, Pobel T, Delétang F, Combarnous Y, Guillou F, Maurel M. Humoral immune response to equine chorionic gonadotropin in ewes: Association with major histocompatibility complex and interference with subsequent fertility. Biol Reprod. 1999; 61:209-218. doi: https://doi.org/10.1095/biolreprod61.1.209.
[18] Roy F, Maurel MC, Combes B, Vaiman D, Cribiu EP, Lantier I, Pobel T, Delétang F, Combarnous Y, Guillou F. The negative effect of repeated equine chorionic gonadotropin treatment on subsequent fertility in Alpine goats is due to a humoral immune response involving the major histocompatibility complex. Biol Reprod. 1999;60(4):805-13. doi: https://doi.org/10.1095/biolreprod60.4.805.
[19] Boselli E, Caboni MF, Sabatini AG, Marcazzan GL, Lercker G. Determination and changes of free amino acids in royal jelly during storage. Apidologie 2003;34(2):129–37. doi: https://doi.org/10.1051/apido:2003011.
[20] Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed Res. 2007;28(5):261–66. doi:https://doi.org/10.2220/biomedres.28.261.
[21] Han B, Li Ch, Zhang L, Fang Y, Feng M, Li J. Novel royal jelly proteins identified by gel-based and gel-free proteomics. J Agric Food Chem. 2011:59(18):10346–55. doi: https://doi.org/10.1021/jf202355n.
[22] Csuka J, Baumgartner J, Dubay J. The effect of royal jelly on some reproductive characters of Japanese quail. Zivocisna Vyroba (Czech J Anim Sci) 1978; 23:395-400.
[23] Khattab M, Radwan A, Afifi E. Physiological effect of royal jelly on female reproductive capacity in rabbits, 4 International Conference on Apiculture in Tropical Climates, 6-10 Nov 1989, Cairo, Egypt.
[24] Khazaei M, Ansarian A, Ghanbari E. New findings on biological actions and clinical applications of royal jelly: A review. J Diet Suppl. 2018;15(5):757–75. doi: https://doi.org/10.1080/19390211.2017.1363843.
[25] Mishima S, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T. Royal jelly has estrogenic effects in vitro and in vivo. J Ethnopharmacol. 2005; 101:215-220. doi: https://doi.org/10.1016/j.jep.2005.04.012.
[26] Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi T, Yamaguchi M. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evid Based Complement Alternat Med. 2006;3(3):339–48. doi: https://doi.org/10.1093/ecam/nel019.
[27] Mahdivand N, Najafi G, Nejati V, Shalizar‐Jalali A, Rahmani F. Royal jelly protects male rats from heat stress‐induced reproductive failure. Andrologia 2018;51(3):13213. doi: https://doi.org/10.1111/and.13213.
[28] Elnagar, SA. Royal jelly counteracts bucks’ “summer infertility”. Anim Reprod Sci. 2010;121(1-2):174–80. doi: https://doi.org/10.1016/j.anireprosci.2010.05.008.
[29] Ghanbari E, Khazaei MR, Khazaei M, Nejati V. Royal Jelly promotes ovarian follicles growth and increases steroid hormones in immature rats. Int J Fertil Steril. 2018;11(4):263-269. doi: https://doi.org/10.22074/ijfs.2018.5156.
[30] Moutsatsou P, Papoutsi Z, Kassi E, Heldring N, Zhao Ch, Tsiapara A, Eleni M, Chrousos GP, Chinou I, Karshikoff A, Nilsson L, Dahlman-Wright K. Fatty acids derived from royal jelly are modulators of estrogen receptor functions. PLoS ONE 2010;5(12): e15594. doi: https://doi.org/10.1371/journal.pone.0015594.
[31] Veshkini A, Mohammadi-Sangcheshmeh A, Ghanem N, Abazari-kia AH, Mottaghi E, Kamaledini R, Deldar H, Ozturk I, Leite E. Oocyte maturation with royal jelly increases embryo development and reduces apoptosis in goats. Anim Reprod. 2018;15(2):124–34. doi: http://dx.doi.org/10.21451/1984-3143-2017-AR986.
[32] Eshtiyaghi M, Deldar H, Ansari Z, Shohreh B. Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization. Theriogenology 2016;86(9):2210–21. doi: https://doi.org/10.1016/j.theriogenology.2016.07.019.
[33] Valiollahpoor A, Deldar H, Ansari Z. Impact of supplementary royal jelly on in vitro maturation of sheep oocytes: genes involved in apoptosis and embryonic development. Syst Biol Reprod Med. 2016:62(1):31–38. doi: https://doi.org/10.3109/19396368.2015.1088102.
[34] Husein MQ, Kridli RT. Reproductive responses following royal jelly treatment administered orally or intramuscularly into progesterone-treated Awassi ewes. Anim Reprod Sci. 2002; 74:45-53. doi: https://doi.org/10.1016/S0378-4320(02)00165-3.
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Alvarez Ramírez, L. ., & Sánchez Cervantes, A. . (2018). ¿Tiene la jalea real un efecto reproductivo en cabras tratadas con progesterona?. Spei Domus, 14(28-29), 1-8. https://revistas.ucc.edu.co/index.php/sp/article/view/3554
En calidad de autor del artículo, declaro que este, es un trabajo original, inédito, de mi creación exclusiva, que no se ha postulado a evaluación simultánea en otra publicación y que no cuenta con algún impedimento de cualquier naturaleza para la concesión de los derechos previstos en este contrato.
En ese sentido, me comprometo a esperar un resultado de evaluación de la revista, antes de considerar su presentación a otro medio, en caso de que la respuesta de publicación no sea positiva; adicionalmente, me comprometo a responder por cualquier acción de reivindicación, plagio u otra clase de reclamación que al respecto pudiera sobrevivir por parte de terceros.
Asimismo, declaro que como autor o coautor, estoy de acuerdo por completo con los contenidos presentados en este trabajo y cedo todos los derechos patrimoniales, es decir, la reproducción, comunicación pública, distribución, divulgación, transformación, puesta a disposición y demás formas de explotación de la obra por cualquier medio o procedimiento, a la revista y a la Editorial de la Universidad Cooperativa de Colombia.
