Does royal jelly have a reproductive effect on progesterone-treated goats?

Lorenzo  Alvarez Ramírez; Alejandra  Sánchez Cervantes

doi:10.16925/2382-4247.2018.01.02

Does royal jelly have a reproductive effect on progesterone-treated goats?

Investigación

https://doi.org/10.16925/2382-4247.2018.01.02

Lorenzo Alvarez Ramírez Ver Biografía

Universidad Nacional Autónoma de México

Alejandra Sánchez Cervantes Ver Biografía

Universidad Nacional Autónoma de México

Introduction: Some methods for inducing/synchronizing oestrus and ovulation in goats require the injection of equine chorionic gonadotrophin (eCG). The objective of this study was to determine whether royal jelly (RJ) can be a substitute for eCG in CIDR-treated dairy goats.

Methods: Sixty-six primiparous goats received the CIDR device for twelve days in April. The eCG group (n=22) was injected with 200 IU of the gonadotropin when the intravaginal device was removed; the RJ group (n=22) received a daily intramuscular injection of 1 g of RJ during the period of CIDR treatment; the CIDR group (n=22) did not receive any additional treatment. A fourth group (Con, n=20) was used as control and received no treatment at all. Oestrus response, ovulation and fertility were recorded.

Results: The oestrus percentage was higher in eCG (95%, p<0.05) than in the remaining groups (RJ, 41%; CIDR, 36% and Con, 0%) and occurred at shorter intervals (eCG, 35±2.3; RJ, 66±4.6; CIDR, 59±2; h±se; p<0.05). Ovulation was higher in eCG (91%, p<0.05), and RJ and CIDR were not different between them (50% vs 41%, p>0.05). No ovulation was recorded in the Con group. The percentage of fertile and birthing animals after 148-158 days was greater in the eCG (91%, p<0.05) compared to other groups (RJ, 36%; CIDR, 36%, Con, 0%), whereas it was not different between the RJ, CIDR and Con groups (p>0.05).

Conclusion: There was no evidence of a reproductive effect of RJ on progesterone-treated goats.

Keywords: progesterone treatments, royal jelly, goats, oestrus induction

[1] Alvarez L. Aspectos de comportamiento y bioestimulación sexual en caprinos, In: AMPCA (Ed.), XX Reunión Nacional sobre Caprinocultura, Culiacán, Sinaloa. México, 2005. pp. 39-57.
[2] Simões J. Recent Advances on Synchronization of Ovulation in Goats, out of Season, for a More Sustainable Production. Asian Pac J Reprod. 2015; 4(2):157–65. https://doi.org/10.1016/S2305-0500(15)30014-2.
[3] Wheaton JE, Carlson KM, Windels HF, Johnston LJ. CIDR: A new progesterone-releasing intravaginal device for induction of estrus and cycle control in sheep and goats. Anim Reprod Sci. 1993; 33:127-141. doi: https://doi.org/10.1016/0378-4320(93)90111-4.
[4] Freitas VJF, Baril G, Saumande J. Estrus synchronization in dairy goats: use of fluorogestone acetate vaginal sponges or norgestomet ear implants. Anim Reprod Sci. 1997; 46:237-244. doi: https://doi.org/10.1016/S0378-4320(96)01614-4.
[5] Wildeus S. Current concepts in synchronization of estrus: Sheep and goats. J Anim Sci. 2000; 77:1-14. doi: https://doi.org/10.2527/jas2000.00218812007700ES0040x.
[6] Menchaca A, Rubianes E. New treatments associated with timed artificial insemination in small ruminants. Reprod Fertil Devel. 2004; 16:403-413. doi: https://doi.org/10.1071/RD04037.
[7] Whitley NC, Jackson DJ. An update on estrus synchronization in goats: A minor species. J Anim Sci. 2004;82: E270-276. doi: https://doi.org/10.2527/2004.8213_supplE270x.
[8] Hamra AH, McNally JW, Marcek JM, Carlson KM, Wheaton JE. Comparison of progesterone sponges, cronolone sponges and controlled internal drug release dispensers on fertility in anestrous ewes. Anim Reprod Sci. 1989; 18:219-226. doi: https://doi.org/10.1016/0378-4320(89)90023-7.
[9] Umberger SH, Jabbar G, Lewis GS. Seasonally anovulatory ewes fail to respond to progestogen treatment in the absence of gonadotropin stimulation. Theriogenology 1994; 42:1329-1336. doi: https://doi.org/10.1016/0093-691X(94)90253-F.
[10] Zaiem I, Tainturier D, ChemLi J, Soltani M. Vaginal sponges and different PMSG doses to improve breeding performances of Black Thibar ewes. Rev Méd Vét 1996; 147:305-310.
[11] Wheaton JE, Pohl HA, Windels HF. Effects of melatonin and progesterone administered to ewes in spring and summer. J Anim Sci. 1990;68(4):923–30. doi: https://doi.org/10.2527/1990.684923x.
[12] Alifakiotis T, Michailidis I, Gavrilidis G. Induced breeding in anestrous milking ewes of dairy breeds: Comparison of norgestomet, medroxyprogesterone and fluorogestone in two regimes of PMSG. Theriogenology 1982; 17:603-610. doi: https://doi.org/10.1016/0093-691X(82)90058-9.
[13] Ritar AJ, Salamon S, Ball PD, O’May PJ. Ovulation and fertility in goats after intravaginal device-PMSG treatment. Small Rumin Res. 1989;2(4):323–31. doi: https://doi.org/10.1016/0921-4488(89)90027-8.
[14] Langford GA. Influence of PMSG and time of artificial insemination on fertility of progestogen-treated sheep in confinement. J Anim Sci. 1982;54(6):1205–11. doi: https://doi.org/10.2527/jas1982.5461205x.
[15] Quintero-Elisea JA, Macías-Cruz U, Álvarez-Valenzuela FD, Correa-Calderón A, González-Reyna A, Lucero-Magaña FA, Soto-Navarro SA, Avendaño-Reyes L. The effects of time and dose of pregnant mare serum gonadotropin (PMSG) on reproductive efficiency in hair sheep ewes. Trop Anim Heal Prod. 2011;43(8):1567–73. doi: https://doi.org/10.1007/s11250-011-9843-z.
[16] Bodin L, Drion PV, Remy B, Brice G, Cognié Y, Beckers JF. Anti-PMSG antibody levels in sheep subjected annually to oestrus synchronisation. Reprod Nutr Dev. 1997; 37:651-660. doi: https://doi.org/10.1051/rnd:19970604.
[17] Roy F, Combes B, Vaiman D, Cribiu E, Pobel T, Delétang F, Combarnous Y, Guillou F, Maurel M. Humoral immune response to equine chorionic gonadotropin in ewes: Association with major histocompatibility complex and interference with subsequent fertility. Biol Reprod. 1999; 61:209-218. doi: https://doi.org/10.1095/biolreprod61.1.209.
[18] Roy F, Maurel MC, Combes B, Vaiman D, Cribiu EP, Lantier I, Pobel T, Delétang F, Combarnous Y, Guillou F. The negative effect of repeated equine chorionic gonadotropin treatment on subsequent fertility in Alpine goats is due to a humoral immune response involving the major histocompatibility complex. Biol Reprod. 1999;60(4):805-13. doi: https://doi.org/10.1095/biolreprod60.4.805.
[19] Boselli E, Caboni MF, Sabatini AG, Marcazzan GL, Lercker G. Determination and changes of free amino acids in royal jelly during storage. Apidologie 2003;34(2):129–37. doi: https://doi.org/10.1051/apido:2003011.
[20] Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed Res. 2007;28(5):261–66. doi:https://doi.org/10.2220/biomedres.28.261.
[21] Han B, Li Ch, Zhang L, Fang Y, Feng M, Li J. Novel royal jelly proteins identified by gel-based and gel-free proteomics. J Agric Food Chem. 2011:59(18):10346–55. doi: https://doi.org/10.1021/jf202355n.
[22] Csuka J, Baumgartner J, Dubay J. The effect of royal jelly on some reproductive characters of Japanese quail. Zivocisna Vyroba (Czech J Anim Sci) 1978; 23:395-400.
[23] Khattab M, Radwan A, Afifi E. Physiological effect of royal jelly on female reproductive capacity in rabbits, 4 International Conference on Apiculture in Tropical Climates, 6-10 Nov 1989, Cairo, Egypt.
[24] Khazaei M, Ansarian A, Ghanbari E. New findings on biological actions and clinical applications of royal jelly: A review. J Diet Suppl. 2018;15(5):757–75. doi: https://doi.org/10.1080/19390211.2017.1363843.
[25] Mishima S, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T. Royal jelly has estrogenic effects in vitro and in vivo. J Ethnopharmacol. 2005; 101:215-220. doi: https://doi.org/10.1016/j.jep.2005.04.012.
[26] Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi T, Yamaguchi M. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evid Based Complement Alternat Med. 2006;3(3):339–48. doi: https://doi.org/10.1093/ecam/nel019.
[27] Mahdivand N, Najafi G, Nejati V, Shalizar‐Jalali A, Rahmani F. Royal jelly protects male rats from heat stress‐induced reproductive failure. Andrologia 2018;51(3):13213. doi: https://doi.org/10.1111/and.13213.
[28] Elnagar, SA. Royal jelly counteracts bucks’ “summer infertility”. Anim Reprod Sci. 2010;121(1-2):174–80. doi: https://doi.org/10.1016/j.anireprosci.2010.05.008.
[29] Ghanbari E, Khazaei MR, Khazaei M, Nejati V. Royal Jelly promotes ovarian follicles growth and increases steroid hormones in immature rats. Int J Fertil Steril. 2018;11(4):263-269. doi: https://doi.org/10.22074/ijfs.2018.5156.
[30] Moutsatsou P, Papoutsi Z, Kassi E, Heldring N, Zhao Ch, Tsiapara A, Eleni M, Chrousos GP, Chinou I, Karshikoff A, Nilsson L, Dahlman-Wright K. Fatty acids derived from royal jelly are modulators of estrogen receptor functions. PLoS ONE 2010;5(12): e15594. doi: https://doi.org/10.1371/journal.pone.0015594.
[31] Veshkini A, Mohammadi-Sangcheshmeh A, Ghanem N, Abazari-kia AH, Mottaghi E, Kamaledini R, Deldar H, Ozturk I, Leite E. Oocyte maturation with royal jelly increases embryo development and reduces apoptosis in goats. Anim Reprod. 2018;15(2):124–34. doi: http://dx.doi.org/10.21451/1984-3143-2017-AR986.
[32] Eshtiyaghi M, Deldar H, Ansari Z, Shohreh B. Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization. Theriogenology 2016;86(9):2210–21. doi: https://doi.org/10.1016/j.theriogenology.2016.07.019.
[33] Valiollahpoor A, Deldar H, Ansari Z. Impact of supplementary royal jelly on in vitro maturation of sheep oocytes: genes involved in apoptosis and embryonic development. Syst Biol Reprod Med. 2016:62(1):31–38. doi: https://doi.org/10.3109/19396368.2015.1088102.
[34] Husein MQ, Kridli RT. Reproductive responses following royal jelly treatment administered orally or intramuscularly into progesterone-treated Awassi ewes. Anim Reprod Sci. 2002; 74:45-53. doi: https://doi.org/10.1016/S0378-4320(02)00165-3.
[35] Kridli RT, Husein MQ, Humphrey WD. Effect of royal jelly and GnRH on the estrus synchronization and pregnancy rate in ewes using intravaginal sponges. Small Rumin Res 2003; 49:25-30. doi: https://doi.org/10.1016/S0921-4488(03)00057-9.
[36] Husein MQ, Haddad SG. A new approach to enhance reproductive performance in sheep using royal jelly in comparison with equine chorionic gonadotropin. Anim Reprod Sci. 2006; 93:24-33. doi: https://doi.org/10.1016/j.anireprosci.2005.06.012.
[37] Siliceo C. Uso de la jalea real como sustituto de la eCG en cabras primalas tratadas con el dispositivo CIDR durante la estación de anestro. Tesis de Licenciatura. Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, 2009, p. 44.
[38] Carlson KM, Pohl HA, Marcek JM, Muser RK, Wheaton JE. Evaluation of progesterone controlled internal drug release dispensers for synchronization of estrus in sheep. Anim Reprod Sci. 1989; 18:205-218. doi: https://doi.org/10.1016/0378-4320(89)90022-5.
[39] Mutiga ER, Mukasa-Mugerwa E. Effect of the method of estrus synchronization and PMSG dosage on estrus and twinning in Ethiopian Menze sheep. Theriogenology 1992; 38:727-734. doi: https://doi.org/10.1016/0093-691X(92)90035-P.
[40] Oliveira MAL, Guido SI, Lima PF. Comparison of different protocols used to induce and synchronize estrus cycle of Saanen goats. Small Rumin Res. 2001; 40:149-153. doi: https://doi.org/10.1016/S0921-4488(00)00222-4.
[41] Kridli RT, Al-Khetib SS. Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Anim Reprod Sci. 2006; 92:75-85. doi: https://doi.org/10.1016/j.anireprosci.2005.05.021.
[42] Dutra P, Barbosa L, Santana A, Aguiar C, Souza R, Cardoso B, Araújo L, Araújo R. Morfometria do aparelho genital e resposta superovulatória de coelhas suplementadas com geleia real. Arq Bras Med Vet Zootec. 2013;65(3):699–704. doi: http://dx.doi.org/10.1590/S0102-09352013000300013.
[43] Mani AU, McKelvey WAC, Watson ED. The effects of low level of feeding on response to synchronization of estrus, ovulation rate and embryo loss in goats. Theriogenology 1992; 38:1013-1022. doi: https://doi.org/10.1016/0093-691X(92)90115-8.
[44] Mani AU, McKelvey WAC, Watson ED. Effect of undernutrition on gonadotrophin profiles in non-pregnant, cycling goats. Anim Reprod Sci. 1996; 43:25-33. doi: https://doi.org/10.1016/0378-4320(96)01472-8.
[45] Okada M, Takeuchi Y, Mori Y. Estradiol-dependency of sexual behavior manifestation at the post-LH surge period in ovariectomized goat. J Reprod Develop. 1998; 44:53-58. doi: https://doi.org/10.1262/jrd.44.53.
[46] Mateescu C, Barbulescu D. Enhanced nutritive, functional and therapeutic action of combined bee products in complex food supplements. Roumanian Biotechnol Lett. 1999; 4:163-172.
[47] Lercker G, Capella P, Conte L, Ruini F, Giordani G. Components of royal jelly II. The lipid fraction, hydrocarbons and sterols. J Apic Res. 1982; 21:178-184. doi: https://doi.org/10.1080/00218839.1982.11100538.
[48] Karaali A, Meydanoglu F, Eke D. Studies on composition, freeze-drying and storage of Turkish royal jelly. J Apic Res. 1988;27:182-185. doi: https://doi.org/10.1080/00218839.1988.11100799.
[49] Inoue Si, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, Kurimoto M. Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp Gerontol. 2003;38:965-969. doi: https://doi.org/10.1016/S0531-5565(03)00165-7.
[50] El-Nekeety AA, El-Kholy W, Abbas NF, Ebaid A, Amra HA, Abdel-Wahhab MA. Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon 2007;50:256-269. doi: https://doi.org/10.1016/j.toxicon.2007.03.017.
[51] Jamnik P, Goranovic D, Raspor P. Antioxidative action of royal jelly in the yeast cell. Experimental Gerontology 2007;42:594-600. doi: https://doi.org/10.1016/j.exger.2007.02.002.
[52] Abdelhafiz AT, Muhamad JA. Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility. Int J Gynecol Obstet. 2008;101:146-149. doi: https://doi.org/10.1016/j.ijgo.2007.11.012.
[53] Kushima K, Hasegawa N, Ogawa E. Effects of royal jelly on autonomic imbalance in menopausal women. World Obstet Gynecol. 1973;25:439-443.
[54] Bentrem DJ, Dardes RC, Liu H, MacGregor-Schafer J, Zapf JW, Jordan VC. Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinol. 2001;142:838-846. doi: https://doi.org/10.1210/endo.142.2.7932.
[55] Ritar AJ, Maxwell WMC, Salamon S. Ovulation and LH secretion in the goat after intravaginal progestagen sponge--PMSG treatment. J Reprod Fertil. 1984;72:559-563. doi: https://doi.org/10.1530/jrf.0.0720559.
[56] Gamboa D. Uso del macho como reemplazo de la gonadotropina equina (eCG) en el tratamiento a base del dispositivo CIDR en cabras lecheras, Tesis de Licenciatura, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, 2008, p. 41.

Alvarez Ramírez, L. ., & Sánchez Cervantes, A. . (2018). Does royal jelly have a reproductive effect on progesterone-treated goats?. Spei Domus, 14(28-29), 1-8. https://doi.org/10.16925/2382-4247.2018.01.02

Download Citation

This work is licensed under a Creative Commons Attribution 4.0 International License.

En calidad de autor del artículo, declaro que este, es un trabajo original, inédito, de mi creación exclusiva, que no se ha postulado a evaluación simultánea en otra publicación y que no cuenta con algún impedimento de cualquier naturaleza para la concesión de los derechos previstos en este contrato.

En ese sentido, me comprometo a esperar un resultado de evaluación de la revista, antes de considerar su presentación a otro medio, en caso de que la respuesta de publicación no sea positiva; adicionalmente, me comprometo a responder por cualquier acción de reivindicación, plagio u otra clase de reclamación que al respecto pudiera sobrevivir por parte de terceros.

Asimismo, declaro que como autor o coautor, estoy de acuerdo por completo con los contenidos presentados en este trabajo y cedo todos los derechos patrimoniales, es decir, la reproducción, comunicación pública, distribución, divulgación, transformación, puesta a disposición y demás formas de explotación de la obra por cualquier medio o procedimiento, a la revista y a la Editorial de la Universidad Cooperativa de Colombia.

Issue

Vol. 14 No. 28-29 (2018)

Published

2018-12-28

Downloads

PDF (Spanish)

Metrics

Metrics Loading ...

https://plu.mx/plum/a/?doi=10.16925/2382-4247.2018.01.02