Producción y aplicación de equivalentes epiteliales autólogos para la recuperación de un defecto de fisura palatina en un paciente

Lina María Franco González; Luz Marina Restrepo Múnera

Production and application of autologous epithelial equivalents for the recovery of cleft palate in a patient

Research Articles

Lina María Franco González Ver Biografía

Universidad Cooperativa de Colombia, sede Medellín

Luz Marina Restrepo Múnera Ver Biografía

Introduction: this research paper stems from the project entitled “Production of oral mucosae equivalents for cleft lip and palate patients” undertaken by the “Tissue engineering and cell therapy” research group of the Universidad de Antioquia. One of the most frequent alterations in the oral cavity is the cleft lip and palate (cl/p) defect. Depending on the proportion and extension of the damage, conventional surgical procedures are often only partially successful. The problems are mainly due to deficiencies of donor tissue and to adjacent, concerned structures. Through tissue engineering numerous researchers have developed oral mucosae equivalents that make more tissue available for the treatment of these defects.

Materials and methods: the application of these substitutes reduces morbility in donor sites, and reestablishes the recovery and functions of affected tissue. Due to the high frequency of cl/p, we propose to develop an autologous oral mucosa substitute as a therapeutic alternative for patients with these defects. In this study, we produced the substitute from autologous tissue. We conducted studies to determine the characteristics of the equivalent for it to meet the conditions to be applied to the patient, who underwent periodic clinical monitoring to assess recovery.

Results: we observed a decrease in the defect with good cicatrization. On a histological level, we observed the presence of collagen fibers as a support matrix.

Conclusions: with this new therapeutic alternative we mean to reduce the morbidity of donor sites and increase the availability of tissue in a short time for the rehabilitation of patients

Keywords: oral mucous equivalent, tissue engineering, clef lip and palate

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Production and application of autologous epithelial equivalents for the recovery of cleft palate in a patient. (2014). Revista Nacional De Odontología, 8(14), 17-23. https://revistas.ucc.edu.co/index.php/od/article/view/280

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Production and application of autologous epithelial equivalents for the recovery of cleft palate in a patient

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