Efectos teratogénicos de insecticidas organofosforados en la etiología de labio y paladar hendido: revisión de literatura

Jesús Gabriel Ortega Miller; Salomón Yezioro Rubinsky; Berta Cecilia Benavides Pinto; Liliana Carolina Báez Quintero

doi:10.16925/od.v12i24.1658

Teratogenic effects of organophosphate insecticides in the etiology of cleft lip palate: literature review

Thematic Review

https://doi.org/10.16925/od.v12i24.1658

Jesús Gabriel Ortega Miller Ver Biografía

Universidad Nacional de Colombia.

Salomón Yezioro Rubinsky Ver Biografía

Universidad Nacional de Colombia.

Berta Cecilia Benavides Pinto Ver Biografía

Universidad Cooperativa de Colombia.

Liliana Carolina Báez Quintero Ver Biografía

Universidad Estadual Paulista

Objective: Evaluate the scientific evidence about the associated relation between the individuals exposure to organophosphates insecticides with the prevalence of non syndromic cleft lip and palate.

Material and Methods: The search of scientific articles was held in the data base of PubMed, Science Direct, Academic Google, Medline, Cochrane and Scielo, published between year 2.000 and 2015, and a series of interviews were held to professionals with a Doctor or Master degree In Toxicology, Public Health, Genetics and Biochemistry that were knowledge about this subject. 25 articles of insecticides were reviewed and 5 semi structural interviews.

Results: A statistical number of studies stablish an association between the exposure to pesticides with teratogenic effects related with the cleft lip and palate; in vivo experimental studies in animals correlate the exposure the organophosphates insecticide Clorpilifos, with the higher prevalence of cleft palate.

Conclusion: some studies found associated relation between the exposure to organophosphates insecticides with increased the incidence of birth abnormalities.

Keywords: agrochemicals, craniofacial anomalies, cleft palate, insecticides, organophosphate insecticides, cleft lip

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Teratogenic effects of organophosphate insecticides in the etiology of cleft lip palate: literature review. (2017). Revista Nacional De Odontología, 13(24). https://doi.org/10.16925/od.v12i24.1658

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Vol. 13 No. 24 (2017)

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2017-02-06

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