Manifestaciones bucales de la inmunodeficiencia: revisión integrativa de la literaria

Iván Porto Puerta; Antonio  Diaz-Caballero; Adel Martínez-Martínez

doi:10.16925/2357-4607.2022.02.06

Oral manifestations of immunodeficiency : integrative review of the literary

Thematic Review

https://doi.org/10.16925/2357-4607.2022.02.06

Iván Porto-Puerta Ver Biografía

Universidad de Cartagena

Antonio Diaz-Caballero Ver Biografía

Universidad de Cartagena

Adel Martínez-Martínez Ver Biografía

Universidad de Cartagena

Introduction: immunodeficiency is the functional alteration of the immune system, which is caused by congenital and / or secondary factors. This dysfunction usually generates not only systemic manifestations, but also at the level of the oral cavity and the perioral area.

Objective: to identify and explain the oral manifestations of immunodeficiency according to the literature.

Methodology: an integrative literature review was carried out, the documents were identified by searching high impact databases; original research, clinical cases, literary reviews and books are selected. No language or publication time restrictions were applied.

Results: Among the most reported oral manifestations are oral thrush, ulcerative lesions, condylomata acuminata, hairy leukoplakia and necrotizing periodontal diseases.

Conclusions: because immunodeficient subjects are more susceptible to suffering from various conditions that could be life-threatening; early identification of oral manifestations is considered essential to facilitate the systemic diagnosis of the immune condition in addition to allowing concomitant treatment of stomatological and systematic manifestations.

Keywords: Oral Medicine, Immunodeficiency, Immunology, Semiology

1. Ballester J , Macías C. El sistema inmunológico: comentarios de interés básico. Rev Cubana Hematol Inmunol Hemoter. 2013; 19:2-3.
2. Monserrat A, Gómez M, Sosa A, Prieto M. Introducción al sistema inmune. Componentes celulares del sistema inmune innato. Rev. Medicine. 2017. 12(24): 1369-78.
3. Fuentes P, Jiménez P, Espinosa P. Inmunodeficiencias del complemento. Revisión de la literatura Parte I. Generalidades y deficiencias de la vía clásica. Alerg Asma Inmunol Pediatr. 2016; 25(3):84-88.
4. Woodland D. Facets of Innate Immunity to Viral Infection. Viral Immunol. 2018; 31(9):595-610
5. Díaz D, Úbeda M, López A, Álvarez M. Respuesta inmune innata y sus implicaciones fisiopatológicas. Rev. Medicine. 2017 12 (24):1388-1397
6. Prieto A, Barbarroja J, Haro S, Monserrat J. Respuesta inmune adaptativa y sus implicaciones fisiopatológicas. Rev. Medicine. 2017; 12 (24): 1398-1407
7. Bruscia E, Bonfield T.Innate and Adaptive Immunity in Cystic Fibrosis. Clinics in Chest Medicine. 2016; 37(1): 17 - 29
8. González V, Pérez M, Morón P. Inmunodeficiencias primarias. Rev. Medicine. 2016; 12(21): 1191-1200
9. Turley A. Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe. J Clin Immunol. 2015; 35(2): 199-205.
10. Abdulghani N, González E, Manzardo C, Manel J, Pericás J. Infección por el virus de la inmunodeficiencia humana (VIH). Síndrome de inmunodeficiencia adquirida. FMC . 2020; 27 (3): 63-74.
11. Donoso F. Lesiones orales asociadas con la enfermedad del virus de inmunodeficiencia humana en pacientes adultos, una perspectiva clínica. Rev. chil. infectol. 2016; 33(1): 27-35.
12. Marchi L, McEvoy B. The Literature Review: Six Steps to Success. Corwin Press. 2009; Step 2: 42-46.
13. Patton L. Oral lesions associated with human immunodeficiency virus disease. Dent Clin North Am. 2013; 57: 673-98.
14. Katiraee F, Khalaj V, Khosravi AR, Hajiabdolbaghi M. Sequences type analysis of Candida albicans isolates from Iranian human immunodeficiency virus infected patients with oral candidiasis. Act. Méd. Iranica. 2014;52(3):187-91.
15. Li YY, Chen WY, Li X, Li HB, Li HQ, Wang L, et al. Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan Province of China. BMC Infectious Diseases. 2013;13:46.
16. Dos Santos P, McArthur C, Africa C. Multi-drug resistant oral Candida species isolated from HIV-positive patients in South Africa and Cameroon. Diagn Microbiol Infect Dis. 2014; 79(2): 222-237
17. Pakfetrat A, Falaki F, Delavarian Z, Dalirsani Z, Sanatkhani M, Zabihi Marani M. Oral Manifestations of Human Immunodeficiency Virus-Infected Patients. Iran J Otorhinolaryngol. 2015; 27 (78): 43-54.
18. Gow NA, van de Veerdonk FL, Brown AJ, Netea MG. Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol 2011;10:112-22.
19. Castro LA, Alvarez MI, Martinez E. Pseudomembranous candidiasis in HIV/AIDS patients in Cali, Colombia. Mycopathologia. 2013;175(1-2):91-8.
20. Rojas T, Rubio E, Viera N, Morón A, Meza L. Características clínicas y microscópicas de Candida albicans. MedULA. 2013; 22(1): 6-10.
21. Rebolledo M, Sanchez M, Bettín A, Mosquera H, Lozano A. Candidiasis bucal en pacientes con cáncer sometidos a quimioterapia. Rev Cubana Estomatol. 2020; 57(1).
22. Harris J, Herrera A. Candidiasis bucal en pacientes VIH/SIDA asociada a niveles de linfocitos T CD4 y terapia antirretroviral. Rev Cubana Estomatol. 2016;53(1),
23. Estrada G, Marquez M, Diaz J, Aguero L. Candidiasis bucal en pacientes con diabetes mellitus. MEDISAN. 2015; 19(11):1317
24. Jose R, Chandra S, Puttabuddi J, Vellappally S, Al Khuraif A, Halawany H, et al. Prevalence of oral and systemic manifestations in pediatric HIV cohorts with and without drug therapy. Current HIV Research. 2013;11(6):498-505.
25. Rosa E, Miramontes M, Sánchez Luis, Mondragón A. Colonización e infección bucal por Candida sp. en pacientes diabéticos y no diabéticos con enfermedad renal crónica en diálisis. Nefrología (Madr.) 2013; 33(6): 764-770.
26. Otero E, Peñamaría M, Rodríguez M, Martín B, Blanco A. Candidiasis oral en el paciente mayor. Av Odontoestomatol. 2015; 31(3): 135-148.
27. Pineda J, Cortés A, Uribarren T, Castañon L. Candidosis vaginal. Revisión de la literatura y situación de México y otros países latinoamericanos. Rev. Méd. Risaralda 2017; 23(1): 38-44.
28. Sulbaran A. Leucoplasia Pilosa bucal. Presentación de caso clínico. Act. Odonto. Venz. 2014; 52(1).
29. García P. Vallejo M, García J, Seoane J. Enfoque del diagnóstico y tratamiento de la leucoplasia oral. Artículos Originales Otorrinolaringología. 2015; 1:1-8.
30. Palmerín A, Cantero A, Tejero M. Leucoplasia oral [Oral leukoplakia]. Aten Primaria. 2020; 52(1):59-60.
31. Van der Waall I. Oral leukoplakia the ongoing discussion on definition and terminology. Med Oral Patol Oral Cir Bucal. 2015; 20:e685–e692.
32. Mortazavi H, Safi Y, Baharvand M, Jafari S, Anbari F, Rahmani S. Oral white lesions: An updated clinical diagnostic decision tree. Dent J (Basel) 2019;7: E15.
33. Villa A, Sonis S. Oral leukoplakia remains a challenging condition. Oral Dis. 2018; 24(1):179-183.
34. Retamal A, Suazo A, Garrido I, Kalergis A, González P. Evasión de la respuesta inmune por virus herpes simplex. Rev. chil. infectol. 2015; 32( 1 ): 58-70.
35. Gallardo R, Castillo K, Alegria P, Blackburn E. Manifestaciones Orales en pacientes VIH/SIDA del Hospital Base de Valdivia en Chile, un estudio descriptivo de corte transversal. Rev. CES Odonto. 2016; 29 (2): 45-52
36. Cardozo M, Tovar V, Guerra E. Prevalencia de Herpes Bucal en Pacientes VIH Positivos Atendidos en el Centro de Atención a Personas con Enfermedades Infectocontagiosas Durante el Período 1999 - 2004. Acta odontol. Venez. 2009; 47( 1 ): 28-37.
37. Porter S R, Hegarty A, Kaliakatsou F, Hodgson T A, Scully C. Recurrent aphthous stomatitis. Clin Dermatol. 2000; 18: 569-78
38. Szpirglas H. Diagnosis of mouth ulcers. Rev Prat. 2002; 52: 375-9
39. Toche P, Salinas J, Guzman A, Afani A, Jadue N. Úlceras orales recurrentes: Características clínicas y diagnóstico diferencial. Rev Chil Infect 2007; 24 (3): 215-219
40. Ferreras J. Enfermedad invasiva gastrointestinal por citomegalovirus resistente a ganciclovir. Revistaseden. 2009; 12(1).
41. Pacho J, Piñol F. Estomatitis aftosa recurrente: Actualización. Rev Cubana Estomatol [Internet]. 2005; 42(1).
42. Rivera C. Essentials of recurrent aphthous stomatitis. Biomed Rep. 2018; 11(2): 47–50.
43. Maksomovskaia LN, Tsarev VN, Davydona MM, Shishchenko VM. The clinico-inmunological characteristics of the course of recurrent aphthous stomatitis. Stomatologia (Mosk) 1995; 74(1):16-9.
44. Maya A, Segovia S, Madrigal S, Abrego I, Salas J. Sarcoma de Kaposi en región oral y maxilofacial, una neoplasia olvidada. Rev Esp Cirug Oral y Maxilofac. 2018; 40( 1 ): 22-26.
45. Pantanowitz L, Khammissa RA, Lemmer J, Feller L. Oral HIV-associated Kaposi sarcoma. J Oral Pathol Med. 2013;42:201-77.
46. Arul A, Kumar A, Verma S, Arul A. Oral Kaposi's sarcoma: Sole presentation in HIV seropositive patient. J Nat Sci Biol Med. 2015; 6(2):459-61.
47. Martínez A, Baldiris R, Díaz A. Papiloma bucal producido por VPH y su relación con carcinoma. Rev. Clín. Med. Fam. 2012;5(2):144-145
48. Carmona M, Porto I, Lanfranch H, Medina W, Werner L, Maturana S. Manifestaciones bucales de enfermedades de transmisión sexual identificadas en tres servicios de estomatología en Sur América. Univ. Salud. 2018; 20(1):82-88
49. Syrjânen S. Oral manifestations of human papillomavirus infections. Eur J Oral Sci. 2018; 126(1): 49-66
50. Donoso F, Ampuero S. HPV genotypes in oral papilloma in Hospital San Juan de Dios HIV (+) patients. Rev. chil. infectol. 2019; 36(4): 469-474.
51. Beachler D, Sugar E, Margolick J, Weber K, Strickler H, Wiley D, et al. Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. Am J Epidemiol 2015; 181(1): 40-53.
52. Cháirez A, Vega M, Zambrano G, García C, Maya G, Cuevas G. Presencia del virus papiloma humano en la cavidad oral: Revisión y actualización de la literatura. Int. J. Odontostomat. 2015; 9(2):233-238.
53. Pringle G. The role of human papillomavirus in oral disease. Dent Clin North Am 2014; 58 (2): 385-99.
54. Herrera D, Figuero E, Shapira L, Jin L, Sanz M. La nueva clasificación de las enfermedades periodontales y periimplantarias. Periodoncia Clinica. 2018; 11: 94-110
55. Albandar J, Susin C, Hughes F. Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations. J. Periodontol. 2018; 45: S171-S189.
56. Chapple I, Mealey B, van Dyke T. Consensus report: Periodontal health and gingival diseases/conditions. J Periodontol. 2018; 45: S68-S77.
57. Bascones A. Enfermedad periodontal necrosante como manifestación de una enfermedad sistémica. Anales de la Real Academia de Doctores de España. 2019; 4 (3): 282-293
58. Atout R, Todescan S. Managing patients with necrotizing ulcerative gingivitis. J Can Dent Assoc. 2013;79: 46-55
59. Maita L, Ramos D, Maita L, Gálvez L. Las enfermedades periodontales necrotizantes. Parte I. Odontol. Sanmarquina. 2014; 17 (1): 35-39.
60. Maita L, Catañeda M, Gálvez L, Maita LM, Navarro C, Ramos D. Enfermedades periodontales necrotizantes II: Aspectos clínicos. Odontol. Sanmarquina. 2016; 19(2): 35 -40.

Oral manifestations of immunodeficiency: integrative review of the literary. (2022). Revista Nacional De Odontología, 18(2), 1-14. https://doi.org/10.16925/2357-4607.2022.02.06

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Vol. 18 No. 2 (2022)

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2022-12-31

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