Gingival carcinoma : a case report
Oral Surgeon, Assistant Professor, Department of Oral Medicine, Gitouc Investigation Group, Faculty of Dentistry, University of Cartagena. Cartagena, Colombia.
email: amartinezm4@unicartagena.edu.co
Oral Pathologist, Professor, Department of Oral Medicine, Metropolitan University, Barranquilla, Colombia.
email: lapatologiaoral@hotmail.com
Periodontist, Professor, Department of Oral Medicine, Director of Gitouc Investigation Group, School of of Dentistry, University of Cartagena. Cartagena, Colombia.
email: adiazc1@unicartagena.edu.co
Squamous-cell carcinoma is a malignant epithelial neoplasm characterized by various clinical manifestations. Present study aimed to report a case of gingival squamous-cell carcinoma in a who patient did not present risk factors associated with the referred neoplasm. A 95-year-old female, attended dental services exposing a rapidly growing, painful proliferative lesion of 6 months of evolution, located in vestibular marginal gingiva, which affected teeth # 33-32-31-43-42-41. According to clinical symptoms and differential diagnosis (central giant cell granuloma and malignant neoplasm), an excisional biopsy was obtained. Diagnosis of referred carcinoma was obtained after three days of patient decease consequent to a severe dyspnea case. Gingival squamous-cell carcinoma is a condition that usually has a good prognostic when diagnostic and treatment are established on time. This study reports a clinical case of a patient who died before having an opportunity to access treatment.
Sankaranarayanan R, Ramadas K, Amarasinghe H, Subramanian S, Johnson N. Oral Cancer: Prevention, early detection, and treatment. In: Gelband H, Jha P, Sankaranarayanan R, Ramadas K, Amarasinghe H, Subramanian S, Johnson N. Cancer: Disease Control Priorities, 3rd ed. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2015. https://bit.ly/3FgXrmH
Chinn SB, Myers JN. Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions. J Clin Oncol. 2015;33(29):3269–3276. https://doi.org/10.1200/JCO.2015.61.2929
Cabral LA, de Carvalho LF, Salgado JA, Brandão AA, Almeida JD. Gingival squamous cell carcinoma: a case report. J Oral Maxillofac Res. 2010;1(3):e6. https://doi.org/10.5037/jomr.2010.1306
Yoon TY, Bhattacharyya I, Katz J, Towle HJ, Islam MN. Squamous cell carcinoma of the gingiva presenting as localized periodontal disease. Quintessence Int 2007;38:97‑102.
Seoane J, Varela‑Centelles PI, Walsh TF, Lopez‑Cedrun JL, Vazquez I. Gingival squamous cell carcinoma: Diagnostic delay or rapid invasion? J Periodontol 2006;77:1229‑33.
Kumar M, Nanavati R, Modi TG, Dobariya C. Oral cancer: Etiology and risk factors: A review. J Can Res Ther 2016;12:458‑63.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G. New insights into human papillomavirus-associated head and neck squamous cell carcinoma. Acta Otorhinolaryngol Ital. 2013 Apr; 33(2): 77-87.
González M, Motta LA, Moreno A, Chala AI, Tupaz HA, García DA. La infección por virus del papiloma humano afecta el pronóstico del cáncer orofaríngeo escamocelular. Revisión de la literatura. UnivOdontol. 2014 Jul-Dic; 33(71): 55-63.
Martinez-Martinez A, Lujan-Pardo MP, Lopez-Aparicio E. High risk serotypes of the human papillomavirus (HPV) in patients with exofitic lesions in the oral cavity. Salud, Barranquilla [online]. 2018, vol.34, n.2 [cited 2019-05-28], pp.420-429. https://www.scielo.org.co/pdf/sun/v34n2/2011-7531-sun-34-02-420.pdf
Neville BW, Day TA. Oral Cancer and Precancerous Lesions. CA Cancer J Clin 2002;52:195-215.
Bharanidharan R, Dineshkumar T, Raghavendhar K, Kumar AR. Squamous cell carcinoma of the gingiva: A diagnostic enigma. J Oral Maxillofac Pathol 2015;19:267.
Lubek J, El-Hakim M, Salama AR, Liu X, Ord RA. Gingival carcinoma: retrospective analysis of 72 patients and indications for elective neck dissection. Br J Oral Maxillofac Surg. 2011;49(3):182-185.
Martinez C, Hernandez M, Martinez B, Adorno D. Frequency of oral squamous cell carcinoma and oral epithelial dysplasia in oral and oropharyngeal mucosa in Chile. Rev. Méd. Chile 2016;144(2):169-174.
Lee KC, Chuang SK, Philipone EM, Peters SM. Which Clinicopathologic Factors Affect the Prognosis of Gingival Squamous Cell Carcinoma: A Population Analysis of 4,345 Cases. Int J Oral Maxillofac Surg. 2017; 46(2): 137-143.
Niu LX, Prognostic factors in mandibular gingival squamous cell carcinoma: A 10-year retrospective study. Int J Oral Maxillofac Surg. 2017; 46(2):137 – 143. https://doi.org/10.1016/j.ijom.2016.09.014
Niu, LX, Yuan Y, Peng X, Guo CB. Risk factors and treatment of contralateral neck recurrence for unilateral oral squamous cell carcinoma: a retrospective study of 1482 cases. Oral Oncol. 2014; 50:1081–1088. https://doi.org/10.1016/j.oraloncology.2014.08.003
Feng Z, Li JN, Niu LX, Guo CB. Supraomohyoid neck dissection in the management of oral squamous cell carcinoma: special consideration for skip metastases at level IV or V. J Oral Maxillofac Surg. 2014;72:1203–1211. https://doi.org/10.1016/j.joms.2013.12.008
Kumar M, Nanavati R, Modi TG, Dobariya C. Oral cancer: Etiology and risk factors: A review. J Can Res Ther 2016;12:458-63.
Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol. 2015;8(9):11884–11894.
Conway DI, Purkayastha M, Chestnutt IG. The changing epidemiology of oral cancer: definitions, trends, and risk factors. Br Dent J. 2018 Nov 9;225(9):867-873. https://doi.org/10.1038/sj.bdj.2018.922
Neville BW, Day TA. Oral Cancer and Precancerous Lesions. CA Cancer J Clin 2002;52:195-215.
Martinez AA, Carmona MC, Diaz A. Behavior of oral cancer at a hospital in Cartagena de indias, Colombia. Rev Cubana Estomatol. 2016;53(2):24-28.
Saman DM. A review of the epidemiology of oral and pharyngeal carcinoma: update. Head Neck Oncol. 2012 Jan 13;4:1. https://doi.org/10.1186/1758-3284-4-1
Hübbers CU, Akgül B. HPV and cancer of the oral cavity. Virulence.;6(3):244–248. https://doi.org/10.1080/21505594.2014.9995700
Martínez Martínez A, Baldiris Ávila R, Díaz Caballero A. Human papillomavirus infection. Relationship with oral squamous cancer, several techniques for detecting its presence. Av. Odontoestomatol 2014;30 (2): 69-78.
https://scielo.isciii.es/pdf/odonto/v30n2/original2.pdf
Guha N, Boffetta P, Wünsch Filho V, Eluf Neto J, Shangina O, Zaridze D, et al. Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: Results of two multicentric case‑control studies. Am J Epidemiol 2007;166:1159‑73
Ye L, Jiang Y, Liu W, Tao H. Correlation between periodontal disease and oral cancer risk: A meta-analysis. J Can Res Ther 2016;12:C237-40.
Yao QW, Zhou DS, Peng HJ, Ji P, Liu DS. Association of periodontal disease with oral cancer: a meta-analysis. Tumour Biol. 2014 Jul;35(7):7073-7. https://doi.org10.1007/s13277-014-1951-8
Niu LX, Feng ZE, Wang DC, Zhang JY, Sun ZP, Guo CB. Prognostic factors in mandibular gingival squamous cell carcinoma: A 10-year retrospective study Int J Oral Maxillofac Surg, 2017 Feb;46(2):137 – 143.
Cabral LA, de Carvalho LF, Salgado JA, Brandão AA, Almeida JD. Gingival squamous cell carcinoma: a case report. J Oral Maxillofac Res. 2010;1(3):e6. 2010. https://doi.org/10.5037/jomr.2010.1306
Copyright (c) 2023 Revista Nacional de Odontología
This work is licensed under a Creative Commons Attribution 4.0 International License.
Every single author of the articles has to declare that is an original unpublished work exclusively created by them, that it has not been submitted for simultaneous evaluation by another publication and that there is no impediment of any kind for concession of the rights provided for in the contract.
In this sense, the authors committed to await the result of the evaluation by the journal Revista Nacional de Odontologia before considering its submission to another medium; in case the response by that publication is positive, additionally, the authors committed to respond for any action involving claims, plagiarism or any other kind of claim that could be made by third parties.
At the same time, the authors have to declare that they are completely in agreement with the conditions presented in their work and that they cede all patrimonial rights. These rights involve reproduction, public communication, distribution, dissemination, transformation, making it available and all forms of exploitation of the work using any medium or procedure, during the term of the legal protection of the work and in every country in the world, to the Universidad Cooperativa de Colombia Press.
Most read articles by the same author(s)
- Adel Martinez Martinez, Kenny Camargo Coronell, Silvana Branca Ferrer, Retrograde periimplantitis. Purpose of a conservative approach , Revista Nacional de Odontología: Vol. 16 No. 2 (2020)